Gastrointestinal stromal tumor (GIST)

Gastrointestinal Stromal Tumor (GIST)

About Gastrointestinal Stromal Tumor (GIST)

Gastrointestinal stromal tumors (GISTs) are a type of tumor that arises from the stroma, or connective tissue, of the gastrointestinal (GI) tract. They most commonly develop in the stomach or small intestine, but can also occur in other parts of the GI tract. GISTs are caused by mutations in certain genes, particularly the KIT gene, which controls cell growth. While the majority of GISTs are benign, some can be malignant and spread to other parts of the body, making early detection and treatment crucial.

Due to their rare nature, GISTs are often misdiagnosed or go unnoticed until they cause significant symptoms. At Apex, we offer specialized diagnostic services and targeted therapies to manage GISTs, aiming to provide patients with personalized care and optimal outcomes.

Symptoms of Gastrointestinal Stromal Tumor (GIST)

Common symptoms of GIST may include:

Abdominal pain or discomfort.
Unexplained weight loss.
A palpable lump in the abdomen.
Nausea or vomiting.
Blood in the stool or vomiting blood.
Difficulty swallowing (if the tumor is in the upper GI tract).
Fatigue and weakness.

Note: GISTs can grow slowly and may not cause symptoms until they are larger or have spread, which is why early detection through routine checkups is important.

Causes of Gastrointestinal Stromal Tumor (GIST)

The exact cause of GIST is not fully understood, but several factors may increase the risk:

Genetic Mutations: Mutations in the KIT gene or PDGFRA gene are commonly associated with GISTs. These genetic changes can lead to abnormal cell growth in the gastrointestinal tract.
Age: GISTs are most commonly diagnosed in adults, especially those over 50 years old.
Family History: A family history of GISTs or other related cancers, such as Carney-Stratakis syndrome, can increase your risk.
Other Genetic Conditions: Certain inherited conditions, such as neurofibromatosis type 1 (NF1), can increase the risk of developing GIST.
Gender: While GISTs affect both men and women, some studies suggest that men may be at a slightly higher risk.

Reducing Your Risk

Maintaining a healthy lifestyle, including regular physical activity, a balanced diet, and avoiding smoking, may help reduce overall cancer risk.
If you have a family history of GIST or other genetic conditions that increase your risk, consider genetic counseling and regular screenings.
Promptly address any gastrointestinal symptoms, such as persistent abdominal pain, unusual weight loss, or digestive issues, to ensure timely diagnosis and treatment.
Regular checkups and screenings, particularly for individuals with genetic conditions like neurofibromatosis, can help detect GISTs early when they are more treatable.

Take Action

If you are experiencing symptoms or have risk factors for gastrointestinal stromal tumors, don’t wait—schedule a consultation with our expert oncology team at Apex. Early detection and personalized treatment are key to managing GISTs effectively. We provide advanced diagnostic services, targeted therapies, and compassionate care tailored to your specific needs. Contact us today for more information and to schedule an appointment.

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3rd Floor, 301 Meraki Arena, Above Croma Store, Sion -Trombay Road, Opp. Godrej RKS, Chembur, Mumbai Pincode - 400 071.

Dr. Amit M. Gupta

Dr Amit M. Gupta (“Maharashtra Ratna”, 2022) is amongst a select few in the country with Post Doctoral Certified Fellowship in Gastrointestinal HPB (Liver, Gallbladder, Pancreas, Stomach) and Retroperitoneal Oncosurgery. He did his post-doctoral from the very prestigious Tata Memorial Hospital. He learned Gastrointestinal HPB and Retroperitoneal Oncosurgery from the well-reckoned Dr. (Prof.) Shailesh Vinayak Shrikhande and Dr. (Prof.) Mahesh Goel.

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